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Pictilisib

Product Name
Pictilisib
CAS No.
957054-30-7
Chemical Name
Pictilisib
Synonyms
CS-23;RG7321;GDC-01;GNE0941;GDC-0941;GNE 0941;GNE-0941;Pictilisib;pictrelisib;GDC-0941, >=98%
CBNumber
CB41872141
Molecular Formula
C23H27N7O3S2
Formula Weight
513.64
MOL File
957054-30-7.mol
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Pictilisib Property

Melting point:
>200oC (dec.)
Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
form 
White powder solid.
pka
12.22±0.40(Predicted)
color 
White/off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11600
Product name
GDC-0941
Purity
≥98%
Packaging
10mg
Price
$134
Updated
2024/03/01
Cayman Chemical
Product number
11600
Product name
GDC-0941
Purity
≥98%
Packaging
50mg
Price
$333
Updated
2024/03/01
Cayman Chemical
Product number
11600
Product name
GDC-0941
Purity
≥98%
Packaging
100mg
Price
$531
Updated
2024/03/01
Biorbyt Ltd
Product number
orb61040
Product name
GDC-0941, Free Base
Purity
>99% pure
Packaging
100mg
Price
$493
Updated
2021/12/16
Biorbyt Ltd
Product number
orb61040
Product name
GDC-0941, Free Base
Purity
>99% pure
Packaging
50mg
Price
$343.4
Updated
2021/12/16
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Pictilisib Chemical Properties,Usage,Production

Description

GDC-0941/Pictilisib (957054-30-7) is a potent and selective inhibitor of class I phosphatidylinositol-3-kinases (PI3K) with significant antitumor activity – IC50’s: PI3Kα = 3nM, PI3Kβ = 33 nM, PI3Kδ = 3 nM, PI3Kγ = 75 nM.1,2?? GDC-0941 is the chemical probe of choice for the pan-inhibition of class I PI3K’s.3?Currently in clinical trials.4

Uses

GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC-0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models. Potent PI3K inhibitor.

Uses

GDC-0941 is a potent and selective oral inhibitor of the class I PI3K. GDC-0941 demonstrated broad spectrum of activity in breast, ovarian, lung, and prostate cancer models. Studies has also shown GDC -0941 may enhance anti-tumor activity of Docetaxel (D494420) in human breast cancer models.

Definition

ChEBI: A sulfonamide composed of indazole, morpholine, and methylsulfonyl-substituted piperazine rings bound to a thienopyrimidine ring.

target

PI3Kα

References

1) Folkes?et al.?(2008),?The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine(GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer;? J.?Med. Chem.,?51?5522 2) Raynaud?et al. (2009),?Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinase: from PI-103 through PI-540, PI620 to the oral agent GDC-0941; Mol. Cancer Ther.,?8?1725 3) Knapp et al. (2013),?A public-private partnership to unlock the untargeted kinome; Nat. Chem. Biol.,?9?3 4) Sarker?et al. (2015),?First-in-human phase I study of pictilisib (GDC-0941), a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in patients with advanced solid tumors; Clin. Cancer Res.,?21?77

Pictilisib Preparation Products And Raw materials

Raw materials

Preparation Products

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Pictilisib Suppliers

Canada 1 China 174 Germany 1 India 4 The Netherlands 1 United Kingdom 3 United States 24 Global 208
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
Advantage
64
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2784
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4662
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6393
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63711
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
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View Lastest Price from Pictilisib manufacturers

Career Henan Chemical Co
Product
Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)- 957054-30-7
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-23

957054-30-7, PictilisibRelated Search:

Motesanib DL-Malic acid Everolimus MK-2206 2HCl CAL-101 Trametinib PLX4032 BEZ235 (NVP-BEZ235, Dactolisib) 2-[(6-Amino-9H-purin-9-yl)methyl]-5-methyl-3-(2-methylphenyl)-4(3H)-quinazolinone N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE NSC 23766 TETRAHYDROCHLORIDE NSC697923 MIF Antagonist, ISO-1 GSK-3β Inhibitor XVIII JNJ-10198409 Compound 23 ERK Inhibitor 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID

  • Pictilisib
  • Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-
  • GDC-0941
  • GDC-0941 free base
  • 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
  • GDC-0941 bismesylate
  • 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine
  • 4-(2-(1H-Indazol-4-yl)-6-((4-(Methylsulfonyl)piperazin-1-yl)Methyl)thieno[3,2-d]
  • 4-{6-[(4-Methanesulfonylpiperazin-1-yl)Methyl]-4-(Morpholin-4-yl)thieno[3,2-d]pyriMidin-2-yl}-1H-indazole
  • 4-(2-(1H-indazol-4-yl)-6-((4-(Methylsulfonyl)piperazin-1-yl)Methyl)thieno[3,2-d]pyriMidin-4-yl)Morpholine
  • 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrim
  • 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine
  • RG7321
  • 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine GDC-0941
  • GDC-0941 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine
  • GDC-0941 (Pictilisib)
  • pictrelisib
  • GDC-0941;GDC 0941;GDC0941
  • 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]py
  • GDC-0941, >=98%
  • Pictilisib, 98%, a potent inhibitor of PI3Kα/δ
  • GDC0941; GDC 0941; RG7321
  • GDC-0941;GDC 0941
  • CS-23
  • GDC-01
  • Pictilisib (GDC0941, RG7321, GNE0941))
  • 4-[2-(1H-indazol-4-yl)-6-[(4-methylsulfonylpiperazin-1-yl)me...
  • PI 3-K Inhibitor XXI GDC-0941 GDC0941
  • GNE 0941
  • GNE0941
  • GNE-0941
  • 957054-30-7
  • C23H27N7O3S2
  • An inhibitor of class I PI3 kinase (PI3K).
  • Inhibitors
  • Akt
  • mTOR
  • PI3K